ParkinsonCanadaV1, Main, Exploration, bibRecord, 001531

Effects of theta burst stimulation on motor cortex excitability in Parkinson's disease

Identifieur interne : 001531 ( Main/Exploration ); précédent : 001530; suivant : 001532

Effects of theta burst stimulation on motor cortex excitability in Parkinson's disease

Auteurs : Orit Zamir [Canada] ; Carolyn Gunraj [Canada] ; ZHEN NI [Canada] ; Filomena Mazzella [Canada] ; Robert Chen [Canada]

Source :

Clinical neurophysiology [ 1388-2457 ] ; 2012.

RBID : Pascal:12-0152454

Descripteurs français

Pascal (Inist)
- Sursaut, Cortex moteur, Excitabilité, Potentialisation, Plasticité synaptique, Stimulation couplée, Potentiel évoqué moteur, Facilitation, Maladie de Parkinson, Pointe positive, Timing, Stimulation magnétique transcrânienne, Electrodiagnostic, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Burst, Electrodiagnosis, Excitability, Facilitation, Human, Motor cortex, Motor evoked potential, Paired stimulation, Parkinson disease, Potentiation, Spike, Synaptic plasticity, Timing, Transcranial magnetic stimulation.

Abstract

Objective: Long-term potentiation (LTP)-like plasticity induced by paired associative stimulation (PAS) is impaired in Parkinson's disease (PD). Intermittent theta burst stimulation (iTBS) is another rTMS protocol that produces LTP-like effects and increases cortical excitability but its effects are independent of afferent input. The aim of the present study was to examine the effects of iTBS on cortical excitability in PD. Methods: iTBS was applied to the motor cortex in 10 healthy subjects and 12 PD patients ON and OFF dopaminergic medications. Motor evoked potential (MEP) before and for 60 min after iTBS were used to examine the changes in cortical excitability induced by iTBS. Paired-pulse TMS was used to test whether intracortical circuits, including short interval intracortical inhibition, intracortical facilitation, short and long latency afferent inhibition, were modulated by iTBS. Results: After iTBS, the control, PD ON and OFF groups had similar increases in MEP amplitude compared to baseline over the course of 60 min. Changes in intracortical circuits induced by iTBS were also similar for the different groups. Conclusions: iTBS produced similar effects on cortical excitability for PD patients and controls. Significance: Spike-timing dependent heterosynaptic LTP-like plasticity induced by PAS may be more impaired in PD than frequency dependent homosynaptic LTP-like plasticity induced by iTBS.

Affiliations:

Canada

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Le document en format XML

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<term>Motor cortex</term>
<term>Motor evoked potential</term>
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<term>Stimulation couplée</term>
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<front><div type="abstract" xml:lang="en">Objective: Long-term potentiation (LTP)-like plasticity induced by paired associative stimulation (PAS) is impaired in Parkinson's disease (PD). Intermittent theta burst stimulation (iTBS) is another rTMS protocol that produces LTP-like effects and increases cortical excitability but its effects are independent of afferent input. The aim of the present study was to examine the effects of iTBS on cortical excitability in PD. Methods: iTBS was applied to the motor cortex in 10 healthy subjects and 12 PD patients ON and OFF dopaminergic medications. Motor evoked potential (MEP) before and for 60 min after iTBS were used to examine the changes in cortical excitability induced by iTBS. Paired-pulse TMS was used to test whether intracortical circuits, including short interval intracortical inhibition, intracortical facilitation, short and long latency afferent inhibition, were modulated by iTBS. Results: After iTBS, the control, PD ON and OFF groups had similar increases in MEP amplitude compared to baseline over the course of 60 min. Changes in intracortical circuits induced by iTBS were also similar for the different groups. Conclusions: iTBS produced similar effects on cortical excitability for PD patients and controls. Significance: Spike-timing dependent heterosynaptic LTP-like plasticity induced by PAS may be more impaired in PD than frequency dependent homosynaptic LTP-like plasticity induced by iTBS.</div>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Effects of theta burst stimulation on motor cortex excitability in Parkinson's disease

Effects of theta burst stimulation on motor cortex excitability in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri